Halogenated Nucleosides
5-fluoro-2'-deoxycytidine
Quick view. We supply 5-fluoro-2'-deoxycytidine as a halogenated nucleoside analog for modified nucleoside, antiviral/antimetabolite and oligonucleotide precursor research. CAS 10356-76-0. Catalog target purity: Specification on request.
Product profile
5-fluoro-2'-deoxycytidine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12FN3O4; molecular weight 245.21).
5-fluoro-2'-deoxycytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-fluoro-2'-deoxycytidine, reported solubility: DMSO: >20mg/mL. Storage: Keep in dark place,Inert atmosphere,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-DEOXY-5-FLUOROCYTIDINE
- 2’-deoxy-5-fluoro-cytidin
- 5-fluor-desoxycytidin
- 5-fluorodeoxycytidine
Useful catalog search terms
- CAS 10356-76-0
- Nucleoside or protected nucleoside intermediate
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H12FN3O4/c10-4-2-13(9(16)12-8(4)11)7-1-5(15)6(3-14)17-7/h,5-7,14-15H,1,3H2,(H2,11,12,16)/t5-,6+,7+/m0/s |
|---|---|
| InChIKey | IDYKCXHJJGMAEV-RRKCRQDMSA-N |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=C(C(=NC2=O)N)F)CO)O |
| Melting point | 196 °C |
| Boiling point | 465℃ |
| Density | 1.82 |
| pKa | 14.03±0.60(Predicted) |
| Form | A crystalline solid |
| Color | white to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-fluoro-2'-deoxycytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-fluoro-2'-deoxycytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0153 and CAS 10356-76-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry.