Sugars
5-O-(Dimethoxytrityl)-1,2-dideoxy-D-Ribose
Quick view. We supply 5-O-(Dimethoxytrityl)-1,2-dideoxy-D-Ribose as a protected or deoxygenated ribofuranose sugar building block for nucleoside and medicinal chemistry synthesis. CAS 95049-01-7. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
5-O-(Dimethoxytrityl)-1,2-dideoxy-D-Ribose is classified as nucleoside or protected nucleoside intermediate (Formula C26H28O5; molecular weight 420.5).
5-O-(Dimethoxytrityl)-1,2-dideoxy-D-Ribose — 1,4-Anhydro-5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-D-erythro-pentitol is used as a reactant in the solution conformation of an abasic DNA undecamer duplex with unpaired thymine. Also used in direct fluorescence monitoring of uracil DNA glycosylase activity in vitro and in bacterial cells using short single-stranded DNA oligomers…
For 5-O-(Dimethoxytrityl)-1,2-dideoxy-D-Ribose, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 1,2-Dideoxy-5-O-DMT-D-ribose
- 5-O-(4,4'-dimethoxytriphenylmethyl)-1,4-anhydro-2-deoxy-D-ribitol
- (2R,3S)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol
- D-erythro-Pentitol, 1,4-anhydro-5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-
Useful catalog search terms
- CAS 95049-01-7
- Nucleoside or protected nucleoside intermediate
- Sugars
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-O-(Dimethoxytrityl)-1,2-dideoxy-D-Ribose can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 5-O-(Dimethoxytrityl)-1,2-dideoxy-D-Ribose or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
1,2-dideoxy ribofuranose
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BX-SUGA-0011Lactose (Galβ1→4Glc)
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BX-SUGA-0012Maltose monohydrate (Glcα1→4Glc)
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BX-SUGA-0013Isomaltose (Glcα1→6Glc)
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BX-SUGA-0014Lactulose (Galβ1→4Fru)
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Frequently asked questions
Can the package size for 5-O-(Dimethoxytrityl)-1,2-dideoxy-D-Ribose be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-SUGA-0140 and CAS 95049-01-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Sugars product family and its named chemistry.