DMTr-protected Nucleosides
5'-O-DMTr-2'-dC(Ac)
Quick view. We supply 5'-O-DMTr-2'-dC(Ac) as a DMTr-protected nucleoside intermediate for selective oligonucleotide building-block synthesis. CAS 100898-63-3. Catalog target purity: ≥96%.
Product profile
5'-O-DMTr-2'-dC(Ac) is classified as nucleoside or protected nucleoside intermediate (Formula C32H33N3O7; molecular weight 571.62).
5'-O-DMTr-2'-dC(Ac) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-dC(Ac), storage: Sealed in dry,2-8°C. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- DMT-Ac-dC
- Ac-DMT-dC
- DMT-NAC-DC
- 5'-DMT-Ac-dC
- DMT-N4-Ac-dC
- N4-Ac-DMT-dC
- N-(1-((2R,4S,5R)
- 5'-O-DMT-N4-Ac-dC
Useful catalog search terms
- CAS 100898-63-3
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection |
|---|---|
| Density | 1.28±0.1 g/cm3(Predicted) |
| pKa | 10.28±0.20(Predicted) |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7), a deoxynucleoside, can be used to synthesize of dodecyl phosphoramidite which is the raw material for dod‐DNA (amphiphilic DNA containing an internal hydrophobic region consisting of dodecyl phosphotriester linkages) synthesis.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Related products
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BX-PN-00265'-O-DMTr-2'-F-dC(Bz)
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BX-PN-00285'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rA(Ac)
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-dC(Ac) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0050 and CAS 100898-63-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.