DMTr-protected Nucleosides
5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rU
Quick view. We supply 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rU as a protected LNA thymidine/5-methyluridine intermediate for LNA monomer synthesis. CAS 206055-71-2. Catalog target purity: ≥95%.
Product profile
5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rU is classified as nucleoside or protected nucleoside intermediate (Formula C32H32N2O8; molecular weight 572.61).
5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rU, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- 5'-O-(4,4'-Dimethoxytrityl)-2'-O,4'-C-methylene-5-methyluridine
- 5'-O-DMT-2'-O-4'-C-Locked-5-Me-rU
Useful catalog search terms
- CAS 206055-71-2
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- conformationally locked sugar
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; conformationally locked sugar |
|---|---|
| Density | 1.331±0.06 g/cm3(Predicted) |
| pKa | 9.46±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0033 and CAS 206055-71-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-rU or the named structural feature represented by this product.