DMTr-protected Nucleosides
5'-O-DMTr-2'-O-Me-rG(iBu)
Quick view. We supply 5'-O-DMTr-2'-O-Me-rG(iBu) as a DMTr-protected 2'-O-methyl nucleoside used as a precursor to 2'-OMe amidites, supports and modified RNA building blocks. CAS 114745-26-5. Catalog target purity: Specification on request.
Product profile
5'-O-DMTr-2'-O-Me-rG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C36H39N5O8; molecular weight 669.72).
5'-O-DMTr-2'-O-Me-rG(iBu) — 5''-O-DMT-N2-Isobutyryl-2''-O-methyl-D-guanosine (CAS# 114745-26-5) is a guanosine derivative used in the preparation of synthetic RNA derivatives such as native-like crosslinked duplex RNA for use in biochemical and nanotechnology studies.
For 5'-O-DMTr-2'-O-Me-rG(iBu), reported solubility: Soluble in acetonitrile. Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-OMe-ibu-G
- DMT-2'-OMe-iBut-dG
- 5'-DMT-2'-OMe-ibu-G
- N2-iBu-DMT-2'-OMe-Gr
- 5'-O-DMT-N2-ibu-2'-OMe-rG
- 5'-O-DMT-2'-OMe-Ibu-Guanosine
- 5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine
- 5'-O-DMT-N2-Isobutyryl-2'-O-methyl-D-guanosine
Useful catalog search terms
- CAS 114745-26-5
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-O-methyl modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| pKa | 9.16±0.20(Predicted) |
| Form | Powder |
| Color | White to Pale Yellow |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](OC)[C@@H]1O |&1:25,27,44,47,r| |
| InChIKey | ISQLJOGRNUQHJX-WKLYCMIMNA-N |
| InChI | InChI=1S/C36H39N5O8/c1-21(2)32(43)39-35-38-31-28(33(44)40-35)37-20-41(31)34-30(47-5)29(42)27(49-34)19-48-36(22-9-7-6-8-10-22,23-11-15-25(45-3)16-12-23)24-13-17-26(46-4)18-14-24/h6-18,20-21,27,29-30,34,42H,19H2,1-5H3,(H2,38,39,40,43,44)/t27-,29-,30-,34-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMTr-2'-O-Me-rG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-Me-rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0108 and CAS 114745-26-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.