Protected Nucleosides
5'-O-TBDMS-3'-O-TBDMS-5-(hydroxymethyl)-dC
Quick view. We supply 5'-O-TBDMS-3'-O-TBDMS-5-(hydroxymethyl)-dC as a silyl-protected ribonucleoside intermediate for RNA monomer and specialty nucleoside synthesis. CAS 1257247-39-4. Catalog target purity: ≥95%.
Product profile
5'-O-TBDMS-3'-O-TBDMS-5-(hydroxymethyl)-dC is classified as nucleoside or protected nucleoside intermediate.
5'-O-TBDMS-3'-O-TBDMS-5-(hydroxymethyl)-dC can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-TBDMS-3'-O-TBDMS-5-(hydroxymethyl)-dC, dye-labeled nucleotides or amidites are bulkier than native monomers; incorporation efficiency, label density, photobleaching and light exposure should be controlled.
Names and search terms
Useful catalog search terms
- CAS 1257247-39-4
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- fluorescent label
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection; fluorescent label |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Fluorescent labels enable non-radioactive detection and can reduce downstream staining or secondary-label steps.
Method limitations
- Dye-labeled nucleotides or amidites are bulkier than native monomers; incorporation efficiency, label density, photobleaching and light exposure should be controlled.
These points describe 5'-O-TBDMS-3'-O-TBDMS-5-(hydroxymethyl)-dC or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-TBDMS-3'-O-TBDMS-5-(hydroxymethyl)-dC be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0057 and CAS 1257247-39-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5'-O-TBDMS-3'-O-TBDMS-5-(hydroxymethyl)-dC or the named structural feature represented by this product.