2'-O-MOE Phosphoramidites
DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-CE-Phosphoramidite as a benzoyl-protected MOE 5-methylcytidine amidite for nuclease-resistant therapeutic oligonucleotide synthesis. CAS 163759-94-2. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C50H60N5O10P; molecular weight 922.01).
DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-CE-Phosphoramidite — N4-Benzoyl-5''-O-DMT-2''-O-methylcytidine 3''-CE phosphoramidite (CAS# 163759-94-2) is a nucleotide used in the stereoselective synthesis of nucleoside alkyl-phosphonates.
For DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-CE-Phosphoramidite, storage: Store at -20°C. Form: Powder.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-5-Me-C(Bz) Phosphoramidite
- 2'-O-MOE-5Me-C(Bz)-3'-phosphoramidite
- 5-Me-DMT-2'-O-MOE-C(Bz)-CE-Phosphoramidite
- 5'-O-DMT-2’-MOE-N6-Bz-5-Methycytidine-CE-Phosphoramidite
- N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite
- N4-Bz-5'-O-DMTr-2'-O-(2-methoxyethyl)-5-methylcytidine-3'-CED-phosphoramidite
- 5'-O-DMT-N4-Acetyl-5-methyl-2'-O-(2-methoxyethyl)cytidine 3'-CE phosphoramidite
- 5'-O-DMT-N4-Benzoyl-5-methyl-2'-O-(2-methoxyethyl)cytidine 3'-CE phosphoramidite
Useful catalog search terms
- CAS 163759-94-2
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-MOE modification
- phosphoramidite coupling group
- BX-2OMP-0059
- 2'-O-MOE Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-MOE modification; phosphoramidite coupling group |
|---|---|
| Form | Powder |
| Color | White to Off-white |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=C(C)C(NC(=O)C3=CC=CC=C3)=NC2=O)[C@H](OCCOC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,45,51,r| |
| InChIKey | FLIGVMLIIDVDSN-SQULMOJWNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0081 and CAS 163759-94-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Phosphoramidites product family and its named chemistry.