2'-O-Propargyl Phosphoramidites
[N6-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-propargyl-adenosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite
Quick view. We supply [N6-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-propargyl-adenosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite as a 2'-O-propargyl RNA phosphoramidite for introducing alkyne handles into oligonucleotides. A public CAS number is not assigned for this exact form. Catalog target purity: Specification on request.
Structure confirmation
This item requires structure confirmation before quotation. Send the target structure, CAS number, SMILES, InChI or drawing for our technical review.
Canonical name plus a structure drawing, SMILES, InChI or unambiguous CAS number.
Protecting groups, stereochemistry, salt or counterion, hydration and requested form.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
[N6-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-propargyl-adenosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite is classified as protected oligonucleotide phosphoramidite building block.
[N6-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-propargyl-adenosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For [N6-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-propargyl-adenosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Useful catalog search terms
- Protected oligonucleotide phosphoramidite building block
- alkyne click handle
- phosphoramidite coupling group
- 2'-O-Propargyl Phosphoramidites
Physicochemical data
| Key chemistry motifs | alkyne click handle; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe [N6-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-propargyl-adenosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for [N6-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-propargyl-adenosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OPP-0013, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss [N6-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-propargyl-adenosine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite or the named structural feature represented by this product.