Modified Nucleosides
(S)-cEt-rA
Quick view. We supply (S)-cEt-rA as a constrained ethyl bicyclic adenosine nucleoside used to build high-affinity therapeutic oligonucleotide monomers and intermediates. CAS 1197033-34-3. Catalog target purity: ≥98%.
Product profile
(S)-cEt-rA is classified as nucleoside or protected nucleoside intermediate (Formula C12H15N5O4; molecular weight 293.28).
(S)-cEt-rA can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For (S)-cEt-rA, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- 9H-Purin-6-amine, 9-[2,5-anhydro-6-deoxy-4-C-(hydroxymethyl)-α-L-mannofuranosyl]-
Useful catalog search terms
- CAS 1197033-34-3
- Nucleoside or protected nucleoside intermediate
- conformationally locked sugar
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | conformationally locked sugar |
|---|---|
| Boiling point | 638.5±65.0 °C(predicted) |
| Density | 2.01±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) |
| pKa | 12.99±0.70(predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe (S)-cEt-rA or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for (S)-cEt-rA be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0001 and CAS 1197033-34-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss (S)-cEt-rA or the named structural feature represented by this product.