BX LAB NEWS & INSIGHTS
Technical articles on nucleoside and oligonucleotide chemistry
Practical articles about the questions that come up before you commit to a material: which intermediate survives scale-up, what a purity number is actually measuring, which sulfurizing reagent suits your sequence. Each one ends with the public literature it draws on, so you can check the reasoning rather than take our word for it.
Industry Insights
What deals and clinical results in this field mean for the people supplying its chemistry.
Technical Articles
Literature-linked technical content that answers practical questions before material selection or project review.
How to Choose Nucleoside Intermediates for Scale-Up
Review route robustness, impurity profile, purification strategy, raw-material supply and batch documentation.
Read technical articleKey Quality Attributes for Modified Nucleotides
Review salt form, water content, storage, enzymatic compatibility, purity basis and analytical method selection.
Read technical articleSulfurizing Reagents for Oligonucleotide Synthesis
Compare solubility, reaction rate, byproducts, stability and process compatibility.
Read technical articleProcess Development Challenges in Nucleoside Manufacturing
Review protecting-group strategy, crystallization, residual impurities and reproducibility.
Read technical articleWhat to Consider When Sourcing Cap Analogs
Align cap architecture, purity basis, counterion, storage and IVT workflow requirements.
Read technical articleWhat the Data Says About Stereodefined Phosphorothioate
The literature does not say stereopure is better — it says the pattern matters, and all-Rp fails in vivo.
Read technical articleEnzymatic DNA Synthesis: What It Threatens, and What It Does Not
The papers name two real limits of phosphoramidite chemistry. Then look at what the enzymes actually made.
Read technical articleEstablished Chemistry Buys You a Smaller Regulatory Package
An industry consortium white paper says the quiet part: novel chemistry costs more than synthesis time.
Read technical articleOligonucleotide Capacity Is Measured in Moles, and the Numbers Are Small
What a $126 million plant expansion buys, and why published capacity figures should not be trusted.
Read technical articleCyclic Dinucleotides: Why the Backbone Is Sulfurized
What the phosphorothioate does for a STING agonist, and what the first-in-class phase I actually reported.
Read technical articleGalNAc Linker Chemistry for Oligonucleotide Research
Compare ligand valency, linker architecture, attachmentchemistry and analytical strategy.
Read technical articleArrowhead's P=S Detour to a 5′-Cyclopropyl Phosphonate
A stalled 1,4-addition became a workable cyclopropanation after a temporary P=O-to-P=S redesign.
Read technical articleAntibody-Oligonucleotide Conjugates: Three Coupled Development Problems
Why antibody targeting, conjugation chemistry and oligonucleotide design have to be developed as one system.
Read technical articleUse these resources in project planning
Start with a technical article when comparing a chemistry family or quality attribute. Use the product catalog for a named material, or send a structure and specification when the target requires custom review.