Nucleoside Protection & Derivatization Reagents
1-(Trifluoroacetyl)imidazole (TFAI)
Quick view. An N-acyl imidazole that transfers a trifluoroacetyl group to amines and other nucleophilic substrates. CAS 1546-79-8. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
1-(Trifluoroacetyl)imidazole (TFAI) is classified as trifluoroacetylation and derivatization reagent (Formula C5H3F3N2O; molecular weight 164.09).
1-(Trifluoroacetyl)imidazole (TFAI) — Trifluoroacetylation of amino-functionalized nucleoside intermediates.
For 1-(Trifluoroacetyl)imidazole (TFAI), coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- TFAI
- N-Trifluoroacetylimidazole
- Trifluoroacetylimidazole
- 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone
Useful catalog search terms
- CAS 1546-79-8
- Trifluoroacetylation and derivatization reagent
- Nucleoside Protection & Derivatization Reagents
Physicochemical data
| Key chemistry motifs | N-acyl imidazole; trifluoroacetyl group |
|---|---|
| SMILES | C1=CN(C=N1)C(=O)C(F)(F)F |
| InChI | InChI=1S/C5H3F3N2O/c6-5(7,8)4(11)10-2-1-9-3-10/h1-3H |
| InChIKey | SINBGNJPYWNUQI-UHFFFAOYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Preparation of trifluoroacetyl-protected amines for downstream synthetic steps.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 1-(Trifluoroacetyl)imidazole (TFAI) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Frequently asked questions
Can the package size for 1-(Trifluoroacetyl)imidazole (TFAI) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PDR-0001 and CAS 1546-79-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 1-(Trifluoroacetyl)imidazole (TFAI) or the named structural feature represented by this product.