Cyclic Dinucleotides
2',3'-cGAMP
Quick view. We supply 2',3'-cGAMP as a mixed-linkage cyclic dinucleotide for cGAS-STING pathway and ligand-response research. CAS 1441190-66-4. Catalog target purity: ≥99%.
Product profile
2',3'-cGAMP is classified as cyclic dinucleotide second messenger or analog (Formula C20H24N10O13P2; molecular weight 674.41).
2',3'-cGAMP — 2′,3′-cGAMP sodium salt has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.
For 2',3'-cGAMP, reported solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 10 mg/ml). Storage: -20°C.
Names and search terms
Confirmed or normalized name variants
- 2'-3' cyclic GMP-AMP
- c[G(2',5')pA(3',5')p]
- 2'-O,5'-O-((adenosine-3'-O,5'-O-diyl)bisphosphinico)guanosine
- 5’)pA(3’
- cyclic [G(2’
- 2',3'-cGAMP sodium salt
- 2',3'-cGAMP (free acid)
- Mammalian (non-canonical) CDN
Useful catalog search terms
- CAS 1441190-66-4
- Cyclic Dinucleotides
- Cyclic dinucleotide second messenger or analog
- cyclic dinucleotide topology
Physicochemical data
| Key chemistry motifs | cyclic dinucleotide topology |
|---|---|
| Linkage | One 2'-5' and one 3'-5' phosphodiester linkage |
| Supply form | Dry research material |
| InChI | InChI=1S/C20H24N10O13P2/c21-14-8-15(24-3-23-14)29(4-25-8)18-11(32)12-7(41-18)2-39-45(36,37)43-13-10(31)6(1-38-44(34,35)42-12)40-19(13)30-5-26-9-16(30)27-20(22)28-17(9)33/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s |
| InChIKey | CNVCOPPPOWRJAV-WOWVFUNENA-L |
| SMILES | O=C1N=C(N)NC2=C1N=CN2[C@H](O3)[C@H](OP(OC[C@@H]4[C@@H](O5)[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O4)(O)=O)[C@H](O)[C@H]3COP5(O)=O |
| Boiling point | 1159.9±75.0 °C(Predicted) |
| Density | 2.61±0.1 g/cm3(Predicted) |
| pKa | 0.89±0.70(Predicted) |
| Form | powder |
| Color | white to beige |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2',3'-cGAMP can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Defined linkage isomers and counterion forms allow controlled comparisons across cyclic-dinucleotide assay conditions.
Method limitations
- Activity can depend on linkage stereochemistry, receptor variant, cell entry, salt form and assay format; molar calculations should use the exact supplied form.
These points describe 2',3'-cGAMP or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',3'-cGAMP be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CDN-0001 and CAS 1441190-66-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Cyclic Dinucleotides product family and its named chemistry.
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- Cyclic G(2',5')pA(3',5')p is the metazoan second messenger produced by cGAS
- STING is a direct innate immune sensor of cyclic di-GMP
- Cyclic di-AMP secreted by Listeria monocytogenes activates a host type I interferon response