Modified Nucleosides
2',3'-Dideoxy-2',3'-didehydrothymidine
Quick view. We supply 2',3'-Dideoxy-2',3'-didehydrothymidine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 3056-17-5. Catalog target purity: Specification on request.
Product profile
2',3'-Dideoxy-2',3'-didehydrothymidine is classified as nucleoside or protected nucleoside intermediate (Formula C10H12N2O4; molecular weight 224.21).
2',3'-Dideoxy-2',3'-didehydrothymidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2',3'-Dideoxy-2',3'-didehydrothymidine, reported solubility: Soluble in water, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride. It shows polymorphism (5.9). Storage: −20°C.
Names and search terms
Confirmed or normalized name variants
- stavudine
- 1-[2,3-DIDEOXY-BETA-D-GLYCERO-PENT-2-ENOFURANOSYL]THYMINE
- 1-((2R,5S)-5-HYDROXYMETHYL-2,5-DIHYDRO-FURAN-2-YL)-5-METHYL-1H-PYRIMIDINE-2,4-DIONE
- 2',3'-ANHYDROTHYMIDINE
- 2',3'-DIDEHYDRO-3'-DEOXYTHYMIDINE
- 2',3'-DIHYDRO-2',3'-DEOXYTHYMIDINE
- 3'-DEOXY-2',3'-DIDEHYDROTHYMIDINE
- 3'-deoxythymidin-2'-ene
Useful catalog search terms
- CAS 3056-17-5
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | 1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s |
|---|---|
| InChIKey | XNKLLVCARDGLGL-JGVFFNPUSA-N |
| SMILES | CC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O |
| Melting point | 159-160°C |
| Density | 1.374±0.06 g/cm3(Predicted) |
| pKa | 9.47±0.10(Predicted) |
| Form | neat |
| Color | White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 2',3'-Dideoxy-2',3'-didehydrothymidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',3'-Dideoxy-2',3'-didehydrothymidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0478 and CAS 3056-17-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.