2'-F Nucleosides
2'-Deoxy-2'-fluoro-5-iodouridine
Quick view. We supply 2'-Deoxy-2'-fluoro-5-iodouridine as a 2'-fluoro nucleoside for modified nucleotide, amidite and nucleoside analog synthesis. CAS 55612-21-0. Catalog target purity: Specification on request.
Product profile
2'-Deoxy-2'-fluoro-5-iodouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H10FIN2O5; molecular weight 372.09).
2'-Deoxy-2'-fluoro-5-iodouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-Deoxy-2'-fluoro-5-iodouridine, reported solubility: Acetonitrile: Soluble Methanol: Soluble. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- 1-(2-Deoxy-2-fluoropentofuranosyl)-4-hydroxy-5-iodopyrimidin-2(1H)-one
- FIRU
- 2'-epi-Fialuridine
- 5-Iodo-2'-F-2'-deoxyuridine
- 5-I-2'-deoxy-2'-fluorouridine
- 5-Iodo-2'-Fluoro2'-Deoxyuridine
- 2’-epi-fialuridine, antiviral agent
- Uridine, 2'-deoxy-2'-fluoro-5-iodo-
Useful catalog search terms
- CAS 55612-21-0
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-F Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| InChI | InChI=1S/C9H10FIN2O5/c10-5-6(15)4(2-14)18-8(5)13-1-3(11)7(16)12-9(13)17/h,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5-,6-,8?/m1/s |
| InChIKey | IPVFGAYTKQKGBM-CDRSNLLMSA-N |
| SMILES | O=c1nc(O)c(I)cn1C1O[C@H](CO)[C@@H](O)[C@H]1F |
| Melting point | 216-218 °C |
| Density | 2.18±0.1 g/cm3(Predicted) |
| pKa | 7.94±0.10(Predicted) |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoro-5-iodouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-Deoxy-2'-fluoro-5-iodouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0179 and CAS 55612-21-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry.