Nucleosides & Deoxynucleosides
2'-dU
Quick view. 2'-dU (2'-deoxyuridine) is a uracil DNA nucleoside used in base-excision repair, nucleotide metabolism and modified nucleoside synthesis. CAS 951-78-0. Catalog target purity: ≥99%.
Product profile
2'-dU is classified as nucleoside or protected nucleoside intermediate (Formula C9H12N2O5; molecular weight 228.2).
2'-dU — 2'-Deoxyuridine(951-78-0) is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2'-Deoxyuridines used as labeling substrates include chloro-2'-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of…
For 2'-dU, reported solubility: DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly). Storage: 0-6°C.
Names and search terms
Confirmed or normalized name variants
- 1-(2'-DEOXY-BETA-D-RIBOFURANOSYL)URACIL
- (+)-2'-DEOXYURIDINE
- DEOXYURIDINE-2'
- DU
- URACIL DEOXYRIBOSIDE
- 2’-desoxyuridine
- deoxyriboseuracil
- deoxyuridine
Useful catalog search terms
- CAS 951-78-0
- Nucleoside or protected nucleoside intermediate
- Nucleosides & Deoxynucleosides
Physicochemical data
| Melting point | 167-169 °C(lit.) |
|---|---|
| Boiling point | 370.01°C (rough estimate) |
| Density | 1.3705 (rough estimate) |
| pKa | pKa 9.3(H₂O t = 25) (Uncertain) |
| Form | Powder |
| Color | White to off-white |
| SMILES | OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O |
| InChI | 1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s |
| InChIKey | MXHRCPNRJAMMIM-ATRFCDNQSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-dU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Related products
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BX-NDO-00042'-dG
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BX-NDO-00062'-dT
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Frequently asked questions
Can the package size for 2'-dU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-NDO-0007 and CAS 951-78-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Nucleosides & Deoxynucleosides product family and its named chemistry.