Base-protected Nucleosides
2'-F-dA(Bz)
Quick view. We supply 2'-F-dA(Bz) as a protected 2'-fluoro nucleoside precursor for modified oligonucleotide and nucleotide synthesis. CAS 136834-20-3. Catalog target purity: Specification on request.
Product profile
2'-F-dA(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C17H16FN5O4; molecular weight 373.34).
2'-F-dA(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-F-dA(Bz), storage: Sealed in dry,2-8°C. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- Bz-2'-F-dA
- N6-Bz-2'-F-dA
- N-Benzoyl-2'-deoxy-2'-fluoroadenosine
- N6-Benzoyl-2'-deoxy-2'-fluoroadenosine
- N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine
- 2'-Deoxy-2'-fluoro-N6-benzoyladenosine
- Adenosine, N-benzoyl-2'-deoxy-2'-fluoro-
Useful catalog search terms
- CAS 136834-20-3
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| Density | 1.67±0.1 g/cm3(Predicted) |
| pKa | 7.87±0.43(Predicted) |
| Form | Solid |
| Color | White to off-white |
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](F)[C@@H]1O |
| InChIKey | HLJZTLWDAQVZBU-YAMOITTJSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-F-Bz-A (N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dA(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-F-dA(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0096 and CAS 136834-20-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.