Modified Nucleotides
2'-O-4'-C-Locked-GTP Sodium Salt
Quick view. 2'-O-4'-C-Locked-GTP Sodium Salt (LNA-GTP Sodium Salt) is a guanosine triphosphate analog with a 2'-O-to-4'-C bridge in the sugar. PubChem resolves CAS 1233876-29-3 to the free-acid component, with formula C11H16N5O14P3 and molecular weight 535.19 g/mol; sodium stoichiometry is not specified. CAS 1233876-29-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-4'-C-Locked-GTP Sodium Salt is classified as modified nucleotides.
2'-O-4'-C-Locked-GTP Sodium Salt is useful for high-affinity probes, SNP/mismatch-discrimination studies, antisense designs and short sequence probes.
For 2'-O-4'-C-Locked-GTP Sodium Salt, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- LNA-GTP Sodium Salt
- LNA-G-TP
- 2'-O,4'-C-Locked Guanosine 5'-Triphosphate Sodium Salt
Useful catalog search terms
- BX-MN-0113
- CAS 1233876-29-3
- Modified Nucleotides
Physicochemical data
| CAS basis | Catalog CAS resolves to the free-acid PubChem component; sodium stoichiometry is not specified |
|---|---|
| Salt form | Sodium salt |
| Counterion stoichiometry | Not specified |
| Sugar modification | 2'-O-to-4'-C bridge |
| Structure representation | Catalog drawing uses xNa+; machine-readable identifiers describe the free-acid component |
| PubChem CID (free acid) | 136248408 |
| Molecular formula (free acid) | C11H16N5O14P3 |
| Molecular weight (free acid) | 535.19 g/mol |
| IUPAC name (free acid) | [[(1R,3R,4R,7S)-3-(2-amino-6-oxo-1H-purin-9-yl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-1-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate |
| InChIKey (free acid) | PYKYQYMIAMREBH-HLJYALQUSA-N |
| InChI (free acid) | InChI=1S/C11H16N5O14P3/c12-10-14-7-4(8(18)15-10)13-3-16(7)9-5-6(17)11(28-9,1-26-5)2-27-32(22,23)30-33(24,25)29-31(19,20)21/h3,5-6,9,17H,1-2H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,12,14,15,18)/t5-,6+,9-,11-/m1/s1 |
| SMILES (free acid) | C1[C@]2([C@H]([C@@H](O1)[C@@H](O2)N3C=NC4=C3N=C(NC4=O)N)O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O |
| Connectivity SMILES (free acid) | C1C2(C(C(O1)C(O2)N3C=NC4=C3N=C(NC4=O)N)O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 2'-O-4'-C-Locked-GTP Sodium Salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-4'-C-Locked-GTP Sodium Salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MODN-0169 and CAS 1233876-29-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact BX Lab product, supplied form, lot specification, availability or performance.
Technology platforms
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