2'-O-Me Nucleosides
2'-O-Me-rI
Quick view. We supply 2'-O-Me-rI as a 2'-O-methyl nucleoside for modified RNA monomer, nucleotide and analytical standard workflows. CAS 3881-21-8. Catalog target purity: ≥98%.
Product profile
2'-O-Me-rI is classified as nucleoside or protected nucleoside intermediate (Formula C11H14N4O5; molecular weight 282.25).
2'-O-Me-rI can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-Me-rI, storage: 2-8°C. Form: Powder.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-I
- 2'-OMe-Ir
- 2'-OMe Inosine
- -(O-METHYL)-INOSINE
- 2'-(O-METHYL)-INOSINE
- 2'-O-Methyl-D-inosine
- Inosine, 2'-O-methyl-
- 2'-(O-METHYL)-INOSINE USP/EP/BP
Useful catalog search terms
- CAS 3881-21-8
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| Melting point | 153-156 °C |
| Boiling point | 724.3±60.0 °C(Predicted) |
| Density | 1.84±0.1 g/cm3(Predicted) |
| pKa | 8.92±0.70(Predicted) |
| Form | Powder |
| Color | White to Off-white |
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)O)N=C2)[C@H](OC)[C@@H]1O |
| InChI | InChI=1S/C11H14N4O5/c1-19-8-7(17)5(2-16)20-11(8)15-4-14-6-9(15)12-3-13-10(6)18/h3-5,7-8,11,16-17H,2H2,1H3,(H,12,13,18)/t5-,7-,8-,11-/m1/s |
| InChIKey | HPHXOIULGYVAKW-IOSLPCCCSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rI or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Me-rI be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0005 and CAS 3881-21-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.