Protected Nucleosides
3',5'-Di-O-TBDMS-2'-O-methyluridine
Quick view. A stereodefined protected uridine bearing separate TBDMS ethers at 3'-O and 5'-O and a methyl ether at 2'-O, CAS 367511-37-3. CAS 367511-37-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3',5'-Di-O-TBDMS-2'-O-methyluridine is classified as silyl-protected pyrimidine nucleoside (Formula C22H42N2O6Si2; molecular weight 486.75 g/mol).
3',5'-Di-O-TBDMS-2'-O-methyluridine for protected-nucleoside chemistry and identity research.
For 3',5'-Di-O-TBDMS-2'-O-methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- Uridine, 3',5'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-O-methyl-
Useful catalog search terms
- 367511-37-3
- C22H42N2O6Si2
- 3',5'-bis-O-TBDMS-2'-O-methyluridine
- NZGTXWSGCBMHTB-NXWXRZEISA-N
- PubChem CID 69539383
Physicochemical data
| Systematic name | 1-[(2R,3R,4R,5R)-4-[(tert-butyldimethylsilyl)oxy]-5-[[(tert-butyldimethylsilyl)oxy]methyl]-3-methoxytetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione |
|---|---|
| Protection pattern | 3'-O-TBDMS; 5'-O-TBDMS; 2'-O-methyl |
| Stereochemistry | (2R,3R,4R,5R) ribofuranose assignment |
| PubChem CID | 69539383 |
| InChIKey | NZGTXWSGCBMHTB-NXWXRZEISA-N |
| InChI | InChI=1S/C22H42N2O6Si2/c1-21(2,3)31(8,9)28-14-15-17(30-32(10,11)22(4,5)6)18(27-7)19(29-15)24-13-12-16(25)23-20(24)26/h12-13,15,17-19H,14H2,1-11H3,(H,23,25,26)/t15-,17-,18-,19-/m1/s1 |
| SMILES | CC(C)(C)[Si](C)(C)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=CC(=O)NC2=O)OC)O[Si](C)(C)C(C)(C)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3',5'-Di-O-TBDMS-2'-O-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3',5'-Di-O-TBDMS-2'-O-methyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0368 and CAS 367511-37-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.