Amino-modified Nucleosides
3'-Azido-2', 3'-dideoxyadenosine
Quick view. We supply 3'-Azido-2', 3'-dideoxyadenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 66323-44-2. Catalog target purity: Specification on request.
Product profile
3'-Azido-2', 3'-dideoxyadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H12N8O2; molecular weight 276.25).
3'-Azido-2', 3'-dideoxyadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-Azido-2', 3'-dideoxyadenosine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- Aza
- 3'-Az-ddA
- 3'-N3-Dda
- 3'-Azddado
- Aids000013
- 3'-Azido-dda
- 3'-AZIDO-2'-DEOXY-D-ADENOSINE
- 3'-AZIDO-2',3'-DIDEOXY-D-ADENOSINE
Useful catalog search terms
- CAS 66323-44-2
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C10H12N8O2/c11-9-8-10(14-3-13-9)18(4-15-8)7-1-5(16-17-12)6(2-19)20-7/h3-7,19H,1-2H2,(H2,11,13,14)/t5-,6+,7+/m0/s |
| InChIKey | XDRZJDXXQHFAAE-RRKCRQDMSA-N |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)CO)N=[N+]=[N-] |
| Melting point | 186-187 °C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 3'-Azido-2', 3'-dideoxyadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-Azido-2', 3'-dideoxyadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0226 and CAS 66323-44-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 3'-Azido-2', 3'-dideoxyadenosine or the named structural feature represented by this product.