Amino-modified Nucleosides
3'-Azido-3'-deoxyuridine
Quick view. We supply 3'-Azido-3'-deoxyuridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 70580-88-0. Catalog target purity: Specification on request.
Product profile
3'-Azido-3'-deoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11N5O5; molecular weight 269.214).
3'-Azido-3'-deoxyuridine — 3′-Azido-3′-deoxyuridine is a useful research chemical compound used as a reactant in the synthesis of oligoribonucleotide N3'→P5' phosphoramidates as RNA mimetics.
For 3'-Azido-3'-deoxyuridine, form: Solid.
Names and search terms
Confirmed or normalized name variants
- CTK2G2932
Useful catalog search terms
- CAS 70580-88-0
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C9H11N5O5/c10-13-12-6-4(3-15)19-8(7(6)17)14-2-1-5(16)11-9(14)18/h1-2,4,6-8,15,17H,3H2,(H,11,16,18)/t4-,6-,7-,8-/m1/s |
| InChIKey | WQBCHXWMHQMQKW-XVFCMESISA-N |
| SMILES | C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)N=[N+]=[N-])O |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 3'-Azido-3'-deoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 3'-Azido-3'-deoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-Azido-3'-deoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0230 and CAS 70580-88-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 3'-Azido-3'-deoxyuridine or the named structural feature represented by this product.