Modified Nucleosides
3'-beta-C-Ethynylcytidine
Quick view. We supply 3'-beta-C-Ethynylcytidine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 180300-43-0. Catalog target purity: Specification on request.
Product profile
3'-beta-C-Ethynylcytidine is classified as nucleoside or protected nucleoside intermediate (Formula C11H13N3O5; molecular weight 267.24).
3'-beta-C-Ethynylcytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-beta-C-Ethynylcytidine, reported solubility: DMSO:127.5(Max Conc. mg/mL);477.1(Max Conc. mM) DMF:5.0(Max Conc. mg/mL);18.71(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);37.42(Max Conc. mM). Storage: Store at -20°C.
Names and search terms
Confirmed or normalized name variants
- 3'-c-ethynylcytidine
- ECyd
- TAS 106
- ETHYNYCYTIDINE
- Ethynylcytidine
- 3'-Ethynylcytidine
- cytidine, 3'-c-ethynyl-
- Ethynylcytidine (TAS-106)
Useful catalog search terms
- CAS 180300-43-0
- Nucleoside or protected nucleoside intermediate
- alkyne click handle
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | alkyne click handle |
|---|---|
| InChI | InChI=1S/C11H13N3O5/c1-2-11(18)6(5-15)19-9(8(11)16)14-4-3-7(12)13-10(14)17/h,3-4,6,8-9,15-16,18H,5H2,(H2,12,13,17)/t6-,8+,9-,11-/m1/s |
| InChIKey | JFIWEPHGRUDAJN-DYUFWOLASA-N |
| SMILES | C#C[C@]1([C@H](O[C@H]([C@@H]1O)N2C=CC(=NC2=O)N)CO)O |
| Melting point | 233-235 °C |
| Boiling point | 536.4±60.0 °C(Predicted) |
| Density | 1.61±0.1 g/cm3(Predicted) |
| pKa | 11.54±0.70(Predicted) |
| Form | A solid |
| Color | White to yellow |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 3'-beta-C-Ethynylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
(S)-cEt-rA
Modified Nucleosides · CAS: 1197033-34-3
BX-OP-0069S-Adenosylmethionine (SAM)
Modified Nucleosides · CAS: 485-80-3
BX-MN-0185(R-/S-) 5-Carbamoylhydroxy methyluridine
Modified Nucleosides · CAS: N/A
BX-MN-0186(R-/S-)5-(1-Hydroxy)(methoxycarbonyl)methyl uridine
Modified Nucleosides · CAS: N/A
BX-MN-0187(R-/S-)5-Carboxyhydroxymethyl uridine
Modified Nucleosides · CAS: N/A
BX-MN-0719(R)-N-(2,3-dihydro-1H-indenyl)adenosine
Modified Nucleosides · CAS: 96392-15-3
Frequently asked questions
Can the package size for 3'-beta-C-Ethynylcytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0291 and CAS 180300-43-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 3'-beta-C-Ethynylcytidine or the named structural feature represented by this product.