Sulfurizing Reagents
3-Ethoxy-1,2,4-dithiazoline-5-one (EDITH)
Quick view. A 1,2,4-dithiazoline sulfurizing reagent developed for solid-phase phosphorothioate DNA and RNA synthesis. A public CAS number is not assigned for this exact form. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
3-Ethoxy-1,2,4-dithiazoline-5-one (EDITH) is classified as dithiazoline sulfurizing reagent (Formula C4H5NO2S2; molecular weight 163.2).
3-Ethoxy-1,2,4-dithiazoline-5-one (EDITH) — Sulfurization of phosphite-triester intermediates in automated oligonucleotide synthesis.
For 3-Ethoxy-1,2,4-dithiazoline-5-one (EDITH), confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- EDITH
- 3-Ethoxy-1,2,4-dithiazolin-5-one
Useful catalog search terms
- Dithiazoline sulfurizing reagent
- Sulfurizing Reagents
Physicochemical data
| Key chemistry motifs | 1,2,4-dithiazoline-5-one ring; 3-ethoxy substituent |
|---|---|
| SMILES | CCOC1=NC(=O)SS1 |
| InChI | InChI=1S/C4H5NO2S2/c1-2-7-4-5-3(6)8-9-4/h2H2,1H3 |
| InChIKey | RZIJZXUDFRSADE-UHFFFAOYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Evaluation of rapid sulfur-transfer conditions for protected DNA and RNA sequences.
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Frequently asked questions
Can the package size for 3-Ethoxy-1,2,4-dithiazoline-5-one (EDITH) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-SR-0006, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 3-Ethoxy-1,2,4-dithiazoline-5-one (EDITH) or the named structural feature represented by this product.