Protected Nucleosides
3'-O-TBDMS-2'-F-dU
Quick view. We supply 3'-O-TBDMS-2'-F-dU as a protected 2'-fluoro uridine intermediate for preparing modified uridine monomers and oligonucleotide synthesis reagents. CAS 1445379-59-8. Catalog target purity: Specification on request.
Product profile
3'-O-TBDMS-2'-F-dU is classified as nucleoside or protected nucleoside intermediate (Formula C15H25FN2O5Si; molecular weight 360.45).
3'-O-TBDMS-2'-F-dU — 2''-Deoxy-3''-O-[(1,1-Dimethylethyl)Dimethylsilyl]-2''-Fluorouridine is a useful compound for the synthetic preparation of 4''-halogen containing nucleotide and nucleoside therapeutics.
For 3'-O-TBDMS-2'-F-dU, reported solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated). Storage: -20°C Freezer, Under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- 3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine
- 2'-Deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluorouridine
- Uridine, 2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-
Useful catalog search terms
- CAS 1445379-59-8
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- 2'-fluoro modification
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection; 2'-fluoro modification |
|---|---|
| Melting point | 182 - 185° C |
| Density | 1.23±0.1 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
| Form | Solid |
| Color | White to Off-White |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O[Si](C(C)(C)C)(C)C |
| InChI | InChI=1S/C15H25FN2O5Si/c1-15(2,3)24(4,5)23-12-9(8-19)22-13(11(12)16)18-7-6-10(20)17-14(18)21/h6-7,9,11-13,19H,8H2,1-5H3,(H,17,20,21)/t9-,11-,12-,13-/m1/s |
| InChIKey | KKWGVZHEXOEALO-OJAKKHQRSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 3'-O-TBDMS-2'-F-dU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-O-TBDMS-2'-F-dU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-TBDMS-2'-F-dU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0070 and CAS 1445379-59-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.