Protected Nucleosides
3'-O-TBDMS-2'-O-Me-rG(iBu)
Quick view. We supply 3'-O-TBDMS-2'-O-Me-rG(iBu) as a protected 2'-O-methyl guanosine intermediate for RNA monomer, reverse monomer and specialty phosphoramidite synthesis. CAS 863097-97-6. Catalog target purity: Specification on request.
Product profile
3'-O-TBDMS-2'-O-Me-rG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C21H35N5O6Si; molecular weight 481.62).
3'-O-TBDMS-2'-O-Me-rG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-TBDMS-2'-O-Me-rG(iBu), excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N2-iso-Butyryl-2’-O-methyl-3-TBDMS-guanosine
Useful catalog search terms
- CAS 863097-97-6
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- 2'-O-methyl modification
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection; 2'-O-methyl modification |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| pKa | 8.68±0.20(Predicted) |
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](OC)[C@@H]1O[Si](C(C)(C)C)(C)C |
| InChIKey | CEEYEENCDIBWAI-QEPJRFBGSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3'-O-TBDMS-2'-O-Me-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-TBDMS-2'-O-Me-rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0071 and CAS 863097-97-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.