Modified Nucleosides
4',5'-Didehydro-2',5'-dideoxyuridine
Quick view. We supply 4',5'-Didehydro-2',5'-dideoxyuridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 58096-66-5. Catalog target purity: Specification on request.
Product profile
4',5'-Didehydro-2',5'-dideoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H10N2O4; molecular weight 210.19).
4',5'-Didehydro-2',5'-dideoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 4',5'-Didehydro-2',5'-dideoxyuridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 1-[(2R,4S)-4-Hydroxy-5-methylideneoxolan-2-yl]pyrimidine-2,4(1H,3H)-dione
- Uridine, 4',5'-didehydro-2',5'-dideoxy-
Useful catalog search terms
- CAS 58096-66-5
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H10N2O4/c1-5-6(12)4-8(15-5)11-3-2-7(13)10-9(11)14/h2-3,6,8,12H,1,4H2,(H,10,13,14)/t6-,8+/m0/s |
|---|---|
| InChIKey | GWUGJFCGJLMLER-POYBYMJQSA-N |
| SMILES | C=C1[C@H](C[C@@H](O1)N2C=CC(=O)NC2=O)O |
| Density | 1.47±0.1 g/cm3(Predicted) |
| pKa | 9.34±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 4',5'-Didehydro-2',5'-dideoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 4',5'-Didehydro-2',5'-dideoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0598 and CAS 58096-66-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.