2'-F Nucleosides
5-Bromo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyluridine
Quick view. 5-Bromo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyluridine is a protected 2'-fluoro halonucleoside with CAS 1188522-91-9. CAS 1188522-91-9. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5-Bromo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyluridine is classified as 2'-f nucleosides (Formula C13H14BrFN2O7; molecular weight 409.16).
5-Bromo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyluridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5-Bromo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyluridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 5-Bromo-2'-deoxy-2'-fluorouridine 3',5'-diacetate
Useful catalog search terms
- CAS 1188522-91-9
Physicochemical data
| InChIKey | GXBDBWHTVDEDMG-DNRKLUKYSA-N |
|---|---|
| Systematic name | ((2R,3R,4R,5R)-3-acetoxy-5-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-2-yl)methyl acetate |
| Structural feature | 3',5'-O-acetyl protection with 2'-fluoro and 5-bromo substitution |
| PubChem CID | 91827912 |
| InChI | InChI=1S/C13H14BrFN2O7/c1-5(18)22-4-8-10(23-6(2)19)9(15)12(24-8)17-3-7(14)11(20)16-13(17)21/h3,8-10,12H,4H2,1-2H3,(H,16,20,21)/t8-,9-,10-,12-/m1/s1 |
| SMILES | CC(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=C(C(=O)NC2=O)Br)F)OC(=O)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Bromo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Bromo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0018 and CAS 1188522-91-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.