Modified Nucleosides
5'-Deoxythymidine
Quick view. We supply 5'-Deoxythymidine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 3458-14-8. Catalog target purity: Specification on request.
Product profile
5'-Deoxythymidine is classified as nucleoside or protected nucleoside intermediate (Formula C10H14N2O4; molecular weight 226.23).
5'-Deoxythymidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-Deoxythymidine, reported solubility: ≤10mg/ml in DMSO;16mg/ml in dimethyl formamide. Storage: −20°C.
Names and search terms
Confirmed or normalized name variants
- 1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione
- Thymidine, 5'-deoxy-
- 2',5'-dideoxythymidine
- 5-Methyl-2',5'-dideoxyuridine
- 2',5'-Dideoxy-5-methyluridine
- 1-[(2R,4S,5R)-4-hydroxy-5-methyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-quinone
Useful catalog search terms
- CAS 3458-14-8
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C10H14N2O4/c1-5-4-12(10(15)11-9(5)14)8-3-7(13)6(2)16-8/h4,6-8,13H,3H2,1-2H3,(H,11,14,15)/t6-,7+,8-/m1/s |
|---|---|
| InChIKey | UGUILUGCFSCUKR-GJMOJQLCSA-N |
| SMILES | C[C@@H]1[C@H](C[C@@H](O1)N2C=C(C(=O)NC2=O)C)O |
| Melting point | 192-193 °C(lit.) |
| Density | 1.344±0.06 g/cm3(Predicted) |
| pKa | 9.55±0.10(Predicted) |
| Form | crystalline solid |
| Color | Off-white to light yellow |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5'-Deoxythymidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0487 and CAS 3458-14-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.