Modified Nucleosides
5-Formyl-2'-O-methylcytidine
Quick view. We supply 5-Formyl-2'-O-methylcytidine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 176858-79-0. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
5-Formyl-2'-O-methylcytidine is classified as nucleoside or protected nucleoside intermediate (Formula C11H15N3O6; molecular weight 285.25).
5-Formyl-2'-O-methylcytidine — 5-Formyl-2’-O-methylcytidine or f5Cm, is a nucleoside present in cytoplasmic tRNALeu and it is a modified cytidine present in the first position of the anticodon for decoding UUG and UUA. This modification is regulated by the activity of ALKBH1 and it is the oxidized form of 2’-O-Methyl-5-hydroxymethylcytidine.
For 5-Formyl-2'-O-methylcytidine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5-Formyl-2’-O-methylcytidine,RNA-modified nucleoside f5Cm
Useful catalog search terms
- CAS 176858-79-0
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-Formyl-2'-O-methylcytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-Formyl-2'-O-methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Formyl-2'-O-methylcytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0787 and CAS 176858-79-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5-Formyl-2'-O-methylcytidine or the named structural feature represented by this product.