2'-F Nucleosides
5-Iodo-2'-fluoro-2'-deoxycytidine
Quick view. We supply 5-Iodo-2'-fluoro-2'-deoxycytidine as a 2'-fluoro nucleoside for modified nucleotide, amidite and nucleoside analog synthesis. CAS 80791-93-1. Catalog target purity: Specification on request.
Product profile
5-Iodo-2'-fluoro-2'-deoxycytidine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11FIN3O4; molecular weight 371.1).
5-Iodo-2'-fluoro-2'-deoxycytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-Iodo-2'-fluoro-2'-deoxycytidine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- AG-H-25014
- 2''-DEOXY-2''-FLUORO-5-IODOCYTIDINE
- Cytidine, 2'-deoxy-2'-fluoro-5-iodo-
Useful catalog search terms
- CAS 80791-93-1
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-F Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| InChI | InChI=1S/C9H11FIN3O4/c10-5-6(16)4(2-15)18-8(5)14-1-3(11)7(12)13-9(14)17/h,4-6,8,15-16H,2H2,(H2,12,13,17)/t4-,5-,6-,8-/m1/s |
| InChIKey | GIMSJJHKKXRFGV-UAKXSSHOSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=C(I)C(N)=NC2=O)[C@H](F)[C@@H]1O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2''-Deoxy-2''-fluoro-5-iodocytidine can be used in preparation of cytidine-5-carboxamide modified nucleotide and their incorporation into DNA.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Iodo-2'-fluoro-2'-deoxycytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Iodo-2'-fluoro-2'-deoxycytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0203 and CAS 80791-93-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry.