Protected Nucleosides
5'-O-(4,4'-Dimethyltrityl) uridine
Quick view. We supply 5'-O-(4,4'-Dimethyltrityl) uridine as a protected nucleoside intermediate for DNA/RNA analog synthesis and medicinal chemistry workflows. CAS 81246-79-9. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
5'-O-(4,4'-Dimethyltrityl) uridine is classified as nucleoside or protected nucleoside intermediate (Formula C30H30N2O8; molecular weight 546.57).
5'-O-(4,4'-Dimethyltrityl) uridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-(4,4'-Dimethyltrityl) uridine, reported solubility: DMSO: 250 mg/mL (457.40 mM; Need ultrasonic). Storage: Store at 2-8°C.
Names and search terms
Confirmed or normalized name variants
- 5'-O-(4,4'-Dimethoxytrityl)uridine
- DMT-Ur
- 5'-DMT -rU
- 5'-O-DMT-rU
- DMT-RIBOURIDINE
- 5'-O-DMT-uridine
- 5'-O-DMTr-uridine
- 5'-dimethoxytrityluridine
Useful catalog search terms
- CAS 81246-79-9
- Nucleoside or protected nucleoside intermediate
- Protected Nucleosides
Physicochemical data
| Melting point | 111-112 °C(Solv: ethyl acetate (141-78-6)) |
|---|---|
| Density | 1.343±0.06 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
| Form | Solid |
| Color | White to off-white |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](O)[C@@H]1O |&1:25,27,36,38,r| |
| InChIKey | PCFSNQYXXACUHM-MNBKXICWNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5'-O-(4,4'-Dimethyltrityl) uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0288 and CAS 81246-79-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.