Other Phosphoramidites
5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite
Quick view. A 5'-O-DMTr, 2'-O-methyluridine derivative bearing a 3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite group, CAS 191786-64-8. CAS 191786-64-8. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite is classified as other phosphoramidites (Formula C38H48N3O8P; molecular weight 705.79).
5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite provides a reactive functional group for conjugation, immobilization or linker-extension studies.
For 5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-OMeU-methyl phosphonamidite
Useful catalog search terms
- CAS 191786-64-8
- C38H48N3O8P
- methyl phosphonamidite
- OMQYBRGCCIXKCN-IFQFNZHASA-N
Physicochemical data
| Nucleobase | Uracil |
|---|---|
| 5' protection | O-DMTr |
| 2'-substitution | O-Methyl |
| 3'-function | O-(P-methyl-N,N-diisopropylamino)phosphonamidite |
| Stereochemistry | Four assigned sugar stereocenters; phosphorus center unspecified |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphonamidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-OP-0094 and CAS 191786-64-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.