2'-O-Me Phosphoramidites
6'-O-DMTr-2'-O-Me-5'-Homo-A(Bz)-3'-CE-Phosphoramidite
Quick view. A 5'-homo N6-benzoyl adenosine CE phosphoramidite bearing 6'-O-DMTr and 2'-O-methyl protection for oligonucleotide synthesis research. CAS 2750354-56-2. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
6'-O-DMTr-2'-O-Me-5'-Homo-A(Bz)-3'-CE-Phosphoramidite is classified as 2'-o-me phosphoramidites (Formula C49H56N7O8P; molecular weight 902.00).
6'-O-DMTr-2'-O-Me-5'-Homo-A(Bz)-3'-CE-Phosphoramidite — Protected 2'-O-methyl adenosine 5'-homo phosphoramidite building block for oligonucleotide synthesis research.
For 6'-O-DMTr-2'-O-Me-5'-Homo-A(Bz)-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 6'-O-DMTr-2'-O-methyl-5'-homo-N6-benzoyladenosine-3'-CE-phosphoramidite
Useful catalog search terms
- CAS 2750354-56-2
- C49H56N7O8P
Physicochemical data
| Side-chain modification | 5'-homo with 6'-O-DMTr |
|---|---|
| Base protection | N6-benzoyl |
| Ribose modification | 2'-O-methyl |
| Coupling group | 3'-CE phosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 6'-O-DMTr-2'-O-Me-5'-Homo-A(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 6'-O-DMTr-2'-O-Me-5'-Homo-A(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0023 and CAS 2750354-56-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.