Cap Analogs
CAP G(5')ppp(5')A Ammonium Salt
Quick view. We supply CAP G(5')ppp(5')A Ammonium Salt as a dinucleotide cap analog for studying GpppA-type 5'-cap structures and enzymatic capping/cap-recognition behavior. CAS 10527-47-6. Catalog target purity: ≥98%.
Product profile
CAP G(5')ppp(5')A Ammonium Salt is classified as rna cap analog or cap-related nucleotide (Formula C20H27N10O17P3; molecular weight 772.41).
CAP G(5')ppp(5')A Ammonium Salt can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For CAP G(5')ppp(5')A Ammonium Salt, capping outcome depends on polymerase system, cap-to-NTP ratio, transcript design and purification method.
Names and search terms
Confirmed or normalized name variants
- GpppA
- Guanosine triphosphate adenosine
- guanosine 5'-triphosphate-5'-adenosine
- guanosine-p3-adenosine-5',5'-triphosphate
Useful catalog search terms
- CAS 10527-47-6
- RNA cap analog or cap-related nucleotide
- Cap Analogs
Physicochemical data
| CAS context | The listed CAS refers to the parent/free-acid identity; confirm the supplied salt or counterion in the current specification. |
|---|---|
| Density | 2.61±0.1 g/cm3(Predicted) |
| pKa | 0.94±0.50(Predicted) |
| SMILES | P(OC)(OP(OC1C(O)C(O)C(N2C3=C(N=C2)C(=O)N=C(N)N3)O1)(OOOP(O)(OOOC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=C(N=C2)C(N)=NC=N3)O1)=O)=O)(O)=O |&1:33,34,36,38,r| |
| InChIKey | MIWWLMNICXUZOS-VIAZPARMNA-N |
| InChI | InChI=1S/C20H27N10O17P3/c21-14-8-15(24-3-23-14)29(4-25-8)18-12(33)10(31)6(44-18)1-42-48(36,37)46-50(40,41)47-49(38,39)43-2-7-11(32)13(34)19(45-7)30-5-26-9-16(30)27-20(22)28-17(9)35/h3-7,10-13,18-19,31-34H,1-2H2,(H,36,37)(H,38,39)(H,40,41)(H2,21,23,24)(H3,22,27,28,35)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog.
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Cap analog selection can influence capping efficiency, orientation and downstream translation-related performance.
Method limitations
- Capping outcome depends on polymerase system, cap-to-NTP ratio, transcript design and purification method.
These points describe CAP G(5')ppp(5')A Ammonium Salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for CAP G(5')ppp(5')A Ammonium Salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CA-0008 and CAS 10527-47-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Cap Analogs product family and its named chemistry.