Linker Phosphoramidites
Chemical Phosphorylation Reagent II
Quick view. We supply Chemical Phosphorylation Reagent II as a chemical phosphorylation reagent for introducing terminal phosphate or phosphorylation-compatible handles during oligonucleotide synthesis. CAS 171285-25-9. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
Chemical Phosphorylation Reagent II is classified as protected oligonucleotide phosphoramidite building block (Formula C39H51N2O9P; molecular weight 722.82).
Chemical Phosphorylation Reagent II — O-DMT-2,2-di(ethoxycarbonyl)propan-1,3-diol is a chemical phosphorylation reagent used for the synthesis of 5'-phosphorylated oligonucleotides. It contains the chemical protective group DMT in its structure, which allows for purification through C18 columns or reversed-phase chromatography.
For Chemical Phosphorylation Reagent II, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- CPRⅡ
- [3-DMT-2,2-dicarboxyethyl]propyl(2-cyanoethyl)(N,N-diisopropyl)phosphoramidite
Useful catalog search terms
- CAS 171285-25-9
- Protected oligonucleotide phosphoramidite building block
- phosphoramidite coupling group
- Linker Phosphoramidites
Physicochemical data
| Key chemistry motifs | phosphoramidite coupling group |
|---|---|
| Boiling point | 740.0±60.0 °C(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Chemical Phosphorylation Reagent II can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
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Frequently asked questions
Can the package size for Chemical Phosphorylation Reagent II be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-LP-0028 and CAS 171285-25-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Linker Phosphoramidites product family and its named chemistry.