2'-O-Me Phosphoramidites
DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite as a standard protected 2'-O-methyl adenosine amidite for modified RNA and therapeutic oligonucleotide synthesis. CAS 110782-31-5. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C48H54N7O8P; molecular weight 887.96).
DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite — (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a nucleotide used in the synthesis of native-like crosslinked duplex RNA.
For DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite, reported solubility: Acetonitrile (Sparingly), DMSO (Slightly), Methanol (Slightly). Storage: Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- Ac-dA Phosphoramidite
- -2-((bis(4-methoxyphenyl)
- 2'OMe-A CE PhosphoraMidite
- Bz-2'-OMe-rA Phosphoramidite
- 2'-OMe-A(Bz) Phosphoramidite
- 2'-OMe-Bz-A Phosphoramidite
- -5-(6-Benzamido-9H-purin-9-yl)
- 2'-OMe-Bz-rA -CE Phosphoramidite
Useful catalog search terms
- CAS 110782-31-5
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-methyl modification
- phosphoramidite coupling group
- BX-2OMP-0048
- 2'-O-Me Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification; phosphoramidite coupling group |
|---|---|
| Melting point | 93-95°C |
| Form | powder |
| Color | white to off-white |
| SMILES | CO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(c2ccccc2)(c3ccc(OC)cc3)c4ccc(OC)cc4)O[C@H]1n5cnc6c(NC(=O)c7ccccc7)ncnc56 |
| InChIKey | AZCGOTUYEPXHMJ-DCATYJMPNA-N |
| InChI | InChI=1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-42-40(62-47(43(42)59-7)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0073 and CAS 110782-31-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry.