2'-O-Me Phosphoramidites
DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite
Quick view. We supply DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite as the L-PSM counterpart for stereodefined 2'-O-methyl adenosine oligonucleotide synthesis. It is used where chirality at modified internucleotide linkages is part of the sequence design. CAS 2379296-17-8. Catalog target purity: ≥95%.
Product profile
DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C51H51N6O10PS; molecular weight 971.03).
DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- (L)-PSM-mA-Sp
- DMT-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite
Useful catalog search terms
- CAS 2379296-17-8
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-methyl modification
- phosphoramidite coupling group
- 2'-O-Me Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0032 and CAS 2379296-17-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry.