2'-O-MOE Phosphoramidites
DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-Phosphoramidite
Quick view. We supply DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-Phosphoramidite as an L-PSM stereodefined MOE 5-methylcytidine amidite for chirality-controlled phosphorothioate oligonucleotide synthesis. CAS 2379296-21-4. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C53H57N4O12PS; molecular weight 1005.08).
DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-Phosphoramidite, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- (L)-PSM-moe5C-Sp
- DMT-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-Phosphoramidite
Useful catalog search terms
- CAS 2379296-21-4
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-MOE modification
- phosphoramidite coupling group
- 2'-O-MOE Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-MOE modification; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-(L)-PSM-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0002 and CAS 2379296-21-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Phosphoramidites product family and its named chemistry.