Modified Nucleosides
N1-Methylpseudouridine
Quick view. We supply N1-Methylpseudouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. A public CAS number is not assigned for this exact form. Catalog target purity: Specification on request.
Structure confirmation
This item requires structure confirmation before quotation. Send the target structure, CAS number, SMILES, InChI or drawing for our technical review.
Canonical name plus a structure drawing, SMILES, InChI or unambiguous CAS number.
Protecting groups, stereochemistry, salt or counterion, hydration and requested form.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
N1-Methylpseudouridine is classified as nucleoside or protected nucleoside intermediate.
N1-Methylpseudouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For N1-Methylpseudouridine, modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
Names and search terms
Useful catalog search terms
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
These points describe N1-Methylpseudouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N1-Methylpseudouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0745, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss N1-Methylpseudouridine or the named structural feature represented by this product.
- Pseudouridine-modified mRNA performance study
- Synthetic mRNA capping review
- N1-Methylpseudouridine Directly Modulates Translation Dynamics (2025)
- N1-methylpseudouridine mRNA modification enhances efficiency and specificity of gene overexpression by preventing Prkra-mediated global translation repression. (2025)
- Impact of coding region accessibility and uridine chemistry on translation in mRNA–DNA hybrid origami (2026)
- The mRNACalc webserver accounts for the N1-methylpseudouridine hypochromicity to enable precise nucleoside-modified mRNA quantification. (2024)
- N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation. (2024)