Amino-modified Nucleosides
2'-amino-2'-deoxyadenosine
Quick view. We supply 2'-amino-2'-deoxyadenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 10414-81-0. Catalog target purity: Specification on request.
Product profile
2'-amino-2'-deoxyadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H14N6O3; molecular weight 266.26).
2'-amino-2'-deoxyadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-amino-2'-deoxyadenosine, reported solubility: Soluble in DMSO. Storage: 2-8°C(protect from light).
Names and search terms
Confirmed or normalized name variants
- Jci-2172
- Nsc324326
- 2'-NH2-dA
- 2'-AMINO-D-ADENOSINE
- 2'-Amino-2'-deoxy-D-adenosine
- Adenosine, 2'-amino,-2'-deoxy
- 2'-Amino-2'-deoxyadenosine USP/EP/BP
- 9-(2-Amino-2-deoxy-β-D-ribofuranosyl)-adenine
Useful catalog search terms
- CAS 10414-81-0
- Nucleoside or protected nucleoside intermediate
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | amine functionality |
|---|---|
| InChI | InChI=1S/C10H14N6O3/c11-5-7(18)4(1-17)19-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1,11H2,(H2,12,13,14) |
| InChIKey | CQKMBZHLOYVGHW-UHFFFAOYSA-N |
| SMILES | OCC1OC(N2C=NC=3C(=NC=NC32)N)C(N)C1O |
| Melting point | 190-191 °C |
| Boiling point | 657.6±65.0 °C(Predicted) |
| Density | 2.08±0.1 g/cm3(Predicted) |
| pKa | 13.42±0.70(Predicted) |
| Form | Powder |
| Color | White to Off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-AdA can be used as starting material for the synthesis of 2'-amino nucleotides.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 2'-amino-2'-deoxyadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-amino-2'-deoxyadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0005 and CAS 10414-81-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry.