2'-F Nucleosides
2'-F-dG
Quick view. We supply 2'-F-dG as a 2'-fluoro guanosine analog for modified oligonucleotide chemistry. CAS 78842-13-4. Catalog target purity: Specification on request.
Product profile
2'-F-dG is classified as nucleoside or protected nucleoside intermediate (Formula C10H12FN5O4; molecular weight 285.23).
2'-F-dG can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-F-dG, reported solubility: DMSO: 50 mg/mL (175.30 mM). Storage: Keep in dark place,Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-F-2'-dG
- 2'-deoxy-2'-fluoroguanosine
- 2'-Fluoro -2'-deoxyguanosine
- Guanosine,2'-deoxy-2'-fluoro-
- 2'-Deoxy-2'-fluoroguanosine USP/EP/BP
- 2-amino-9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Useful catalog search terms
- CAS 78842-13-4
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-F Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| Melting point | 262-264 °C(Solv: water (7732-18-5)) |
| Density | 2.17±0.1 g/cm3(Predicted) |
| Form | Powder |
| Color | White to Off-white |
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](F)[C@@H]1O |
| InChI | InChI=1S/C10H12FN5O4/c11-4-6(18)3(1-17)20-9(4)16-2-13-5-7(16)14-10(12)15-8(5)19/h2-4,6,9,17-18H,1H2,(H3,12,14,15,19)/t3-,4-,6-,9-/m1/s |
| InChIKey | UXUZARPLRQRNNX-DXTOWSMRSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dG or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-F-dG be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0183 and CAS 78842-13-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry.