2'-O-MOE Phosphoramidites
2'-O-MOE-U Phosphoramidite
Quick view. We supply 2'-O-MOE-U Phosphoramidite as a standard MOE uridine amidite for antisense and modified RNA oligonucleotide synthesis. CAS 163759-97-5. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2'-O-MOE-U Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C42H53N4O10P; molecular weight 804.86).
2'-O-MOE-U Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For 2'-O-MOE-U Phosphoramidite, storage: 4°C, protect from light. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-rU Phosphoramidite
- 2'-O-MOE-U-CE Phosphoramidite
- 2'-O-MOE-U-3'-phosphoramidite
- DMT-2'-O-MOE-U-CE-Phosphoramidite
- 5'-O-DMT-2'-(2-methoxyethyl)uridine 3'-CE phosphoramidite
- 5'-O-DMT-2'-O-(2-methoxyethyl)uridine 3'-CE phosphoramidite
- 5'-O-DMTr-2'-O-(2-methoxyethyl)-uridine-3'-CED-phosphoramidite
- 5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-uridine-3'-cyanoethyl Phosphoramidite
Useful catalog search terms
- CAS 163759-97-5
- Protected oligonucleotide phosphoramidite building block
- 2'-O-MOE modification
- phosphoramidite coupling group
- 2'-O-MOE Phosphoramidites
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | White to off-white |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OCCOC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,36,42,r| |
| InChIKey | ZLOKLUONKGURQI-LWTSSKLSNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-MOE-U is a phosphoramidite, can be used for oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-U Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-MOE-U Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0062 and CAS 163759-97-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Phosphoramidites product family and its named chemistry.