Cyclic Dinucleotides
cAIMP
Quick view. We supply cAIMP as a mixed-base cyclic dinucleotide for STING ligand-selectivity and nucleotide-signaling studies. CAS 1507367-51-2. Catalog target purity: Specification on request.
Product profile
cAIMP is classified as cyclic dinucleotide second messenger or analog (Formula C20H23N9O13P2; molecular weight 659.40).
cAIMP can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For cAIMP, reported solubility: Aqueous solubility is salt-form and concentration dependent; confirm the current lot specification before preparing a stock. Storage: Store sealed and dry; use the lot-specific CoA for the recommended temperature and hold time.
Names and search terms
Confirmed or normalized name variants
- Cyclic AMP-IMP
- Cyclic adenosine-inosine monophosphate
- cAIMP cyclic dinucleotide
- c-(ApIp)
- 3'-Inosinic acid, adenylyl-(3'→5')-, cyclic nucleotide
Useful catalog search terms
- CAS 1507367-51-2
- Cyclic Dinucleotides
- Cyclic dinucleotide second messenger or analog
- cyclic dinucleotide topology
Physicochemical data
| Key chemistry motifs | cyclic dinucleotide topology |
|---|---|
| Nucleobases | Adenine and hypoxanthine |
| Supply form | Dry research material |
| InChI | InChI=1S/C20H23N9O13P2/c21-15-9-16(23-3-22-15)28(5-26-9)19-11(30)13-7(39-19)1-37-44(35,36)42-14-8(2-38-43(33,34)41-13)40-20(12(14)31)29-6-27-10-17(29)24-4-25-18(10)32/h3-8,11-14,19-20,30-31H,1-2H2,(H,33,34)(H,35,36)(H2,21,22,23)(H,24,25,32)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s |
| InChIKey | SBNULQXUGGEMOY-XPWFQUROSA-N |
| SMILES | C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=CNC4=O)O)OP(=O)(OC[C@@H]5[C@H]([C@H]([C@@H](O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)O)O |
| Boiling point | 1131.2±75.0 °C(Predicted) |
| Density | 2.52±0.1 g/cm3(Predicted) |
| pKa | 0.96±0.70(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Defined linkage isomers and counterion forms allow controlled comparisons across cyclic-dinucleotide assay conditions.
Method limitations
- Activity can depend on linkage stereochemistry, receptor variant, cell entry, salt form and assay format; molar calculations should use the exact supplied form.
These points describe cAIMP or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for cAIMP be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CDN-0016 and CAS 1507367-51-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Cyclic Dinucleotides product family and its named chemistry.
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- Cyclic G(2',5')pA(3',5')p is the metazoan second messenger produced by cGAS
- STING is a direct innate immune sensor of cyclic di-GMP
- Cyclic di-AMP secreted by Listeria monocytogenes activates a host type I interferon response
