LNA Phosphoramidites
DMTr-2'-O-4'-C-Locked-rT-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-4'-C-Locked-rT-3'-CE-Phosphoramidite as an LNA thymidine monomer used to strengthen DNA-like oligos. CAS 206055-75-6. Catalog target purity: ≥98%.
Product profile
DMTr-2'-O-4'-C-Locked-rT-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C41H49N4O9P; molecular weight 772.84).
DMTr-2'-O-4'-C-Locked-rT-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For DMTr-2'-O-4'-C-Locked-rT-3'-CE-Phosphoramidite, reported solubility: DMSO: 250 mg/mL (323.49 mM; Need ultrasonic). Storage: Store at -20°C.
Names and search terms
Confirmed or normalized name variants
- DMTr-LNA-5MeU-3-CED-phosphoramidite
- 2'-O-4'-C-Locked-Tr-CE-Phosphoramidite
- DMT-locT Phosphoramidite configured for ABI
- 5'-O-DMT-2'-O,4'-C-methylene-5-methyluridine 3'-CE-phosphoramidite
- 5'-O-(4, 4'-dimethoxytrityl)-2'-O-4'-C-Locked-thymidine-3'-cyanoethyl Phosphoramidite
- DMT-2'-O-4'-C-Locked-rT-3'-CE-Phosphoramidite
- DMTr-2'-O-4'-C-Locked-rT-3'-2-cyanoethyl phosphoramidite
- LNA-5-Me-U-Phosphoramidite
Useful catalog search terms
- CAS 206055-75-6
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- conformationally locked sugar
- phosphoramidite coupling group
- BX-LP-0020
- LNA Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; conformationally locked sugar; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | White to off-white |
| SMILES | C(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)(C1C=CC(OC)=CC=1)OC[C@@]12CO[C@@H]([C@H](N3C=C(C)C(=O)NC3=O)O1)C2([H])OP(OCCC#N)N(C(C)C)C(C)C |&1:25,28,29,r| |
| InChIKey | STPXOEPMLLHUDQ-USBBLBHBNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe DMTr-2'-O-4'-C-Locked-rT-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
DMTr-2'-O-4'-C-Locked- rC(Ac)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: N/A
BX-LP-0002DMTr-2'-O-4'-C-Locked-5-Me-rC(Ac)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: N/A
BX-LP-0003DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 206055-82-5
BX-LP-0004DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 206055-79-0
BX-LP-0005DMTr-2'-O-4'-C-Locked-rC(Bz)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: N/A
BX-LP-0006DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 709641-79-2
Frequently asked questions
Can the package size for DMTr-2'-O-4'-C-Locked-rT-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-LP-0008 and CAS 206055-75-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss DMTr-2'-O-4'-C-Locked-rT-3'-CE-Phosphoramidite or the named structural feature represented by this product.