2'-O-MOE Phosphoramidites
DMTr-2'-O-MOE-rA(Bz)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-MOE-rA(Bz)-3'-CE-Phosphoramidite as a benzoyl-protected MOE adenosine amidite for therapeutic oligonucleotide synthesis. CAS 251647-53-7. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-MOE-rA(Bz)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C50H58N7O9P; molecular weight 932.01).
DMTr-2'-O-MOE-rA(Bz)-3'-CE-Phosphoramidite — N6-Benzoyl-5''-O-DMT-2''-O-(2-methoxyethyl)adenosine 3''-CE phosphoramidite (CAS# 251647-53-7) is used diagnostically in the screening of insulin-like growth factor-I (IGF-I) and growth hormone receptor (GHR) oligonucleotidic modulators.
For DMTr-2'-O-MOE-rA(Bz)-3'-CE-Phosphoramidite, storage: -20°C. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-Bz-A Phosphoramidite
- 2'-O-MOE-rA(Bz) Phosphoramidite)
- 2'-O-MOE-A(Bz)-3'-phosphoramidite
- 2'-O-MOE-A(Bz)-CE Phosphoramidite
- DMT-2'-O-MOE-A(Bz)-CE-Phosphoramidite
- 5'-O-DMT-N6-Benzoyl-2'-O-(2-methoxyethyl)adenosine 3'-CE phosphoramidite
- N6-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)adenosine 3'-CE phosphoramidite
- DMT-2'-O-MOE-rA(Bz)-3'-CE-Phosphoramidite
Useful catalog search terms
- CAS 251647-53-7
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-MOE modification
- phosphoramidite coupling group
- 2'-O-MOE-A(Bz) Phosphoramidite
- BX-2OMP-0057
- 2'-O-MOE Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-MOE modification; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | White to off-white |
| InChIKey | VPBYBQBHLYRLHG-VCCSSPGHNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-O-MOE-rA(Bz)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe DMTr-2'-O-MOE-rA(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-2OMP-0003DMTr-2'-O-MOE-5-Me-rC(DMTr)-3'-CE-Phosphoramidite
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BX-2OMP-0004DMTr-2'-O-MOE-5-Me-rC-3'-CE-Phosphoramidite
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BX-2OMP-0005DMTr-2'-O-MOE-rA(Bz)-3'- ((2-cyanoethoxy)(diisopropylamino) phosphoramidite)-ethyl-diisopropylphosphoramidite
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Frequently asked questions
Can the package size for DMTr-2'-O-MOE-rA(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0078 and CAS 251647-53-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Phosphoramidites product family and its named chemistry.