2'-O-MOE Phosphoramidites
DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite as an iBu-protected MOE guanosine amidite for ASO/RNA analog synthesis. CAS 251647-55-9. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C47H60N7O10P; molecular weight 913.99).
DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite — 5''-O-DMT-N2-isobutyryl-2''-O-(2-methoxyethyl)-guanosine 3''-CE phosphoramidite (CAS# 251647-55-9) is a nucleotide, and a derivative of guanosine, and is used in the stereochemical sythesis of phosphorothioate oligonucleotides.
For DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite, reported solubility: DMSO: 250 mg/mL (273.53 mM; Need ultrasonic). Storage: 4°C, protect from light.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-O-MOE-G(iBu)-CEP
- DMT-2μ-O-Me-rG(ib) amidite
- 2'-O-MOE-ibu-G Phosphoramidite
- 2'-MOE-G(iBu)-3'-phosphoramidite
- 2'-O-MOE-rG(ibu) Phosphoramidite
- 2'-O-MOE-G(iBu)-CE Phosphoramidite
- DMT-2'-O-MOE-G(iBu)-CE-Phosphoramidite
- 5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine 3'-CE phosphoramidite
Useful catalog search terms
- CAS 251647-55-9
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-MOE modification
- phosphoramidite coupling group
- 2'-O-MOE-G(ibu) Phosphoramidite
- BX-2OMP-0058
- 2'-O-MOE Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-MOE modification; phosphoramidite coupling group |
|---|---|
| Form | Powder |
| Color | White to Off-white |
| InChIKey | LADCDGNEBIQAAU-KEFUZROQNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-MOE-rG(iBu)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0079 and CAS 251647-55-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Phosphoramidites product family and its named chemistry.