2'-O-Me Nucleosides
5'-O-DMTr-N2-dimethylformamidine-2'-O-methylguanosine
Quick view. A protected 2'-O-methyl guanosine intermediate bearing N2-dimethylformamidine and 5'-O-DMTr groups for nucleoside and oligonucleotide synthesis research. CAS 128219-76-1. Catalog target purity: >98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-N2-dimethylformamidine-2'-O-methylguanosine is classified as 2'-o-me nucleosides (Formula C35H38N6O7; molecular weight 654.71).
5'-O-DMTr-N2-dimethylformamidine-2'-O-methylguanosine — Protected 2'-O-methyl guanosine intermediate for nucleoside and oligonucleotide synthesis research.
For 5'-O-DMTr-N2-dimethylformamidine-2'-O-methylguanosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N2-DMF-5'-O-DMT-2'-O-methylguanosine
- N2-dmf-DMT-2'-OMe-Gr
- 5'-O-DMT-N2-dimethylformamidine-2'-O-methylguanosine
Useful catalog search terms
- CAS 128219-76-1
- SBJHBQZDABMKCF-JHZZHVAFSA-N
- PubChem CID 137166363
Physicochemical data
| Base protection | N2-dimethylformamidine |
|---|---|
| Sugar modification | 2'-O-methyl |
| Hydroxyl protection | 5'-O-DMTr |
| PubChem CID | 137166363 |
| InChIKey | SBJHBQZDABMKCF-JHZZHVAFSA-N |
| InChI | InChI=1S/C35H38N6O7/c1-40(2)20-37-34-38-31-28(32(43)39-34)36-21-41(31)33-30(46-5)29(42)27(48-33)19-47-35(22-9-7-6-8-10-22,23-11-15-25(44-3)16-12-23)24-13-17-26(45-4)18-14-24/h6-18,20-21,27,29-30,33,42H,19H2,1-5H3,(H,38,39,43)/t27-,29-,30-,33-/m1/s1 |
| SMILES | CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-N2-dimethylformamidine-2'-O-methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-N2-dimethylformamidine-2'-O-methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0119 and CAS 128219-76-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.