BX LAB PRODUCT CATEGORY
2'-O-Me Phosphoramidites
Quick view. 2′-O-methyl ribonucleoside phosphoramidites for nuclease-resistant RNA, siRNA and antisense oligonucleotide research. This category currently includes 46 products. 2'-O-Me Phosphoramidites products provide protected, sequence-addressable building blocks for solid-phase oligonucleotide synthesis and modified-sequence research.
Category guide
2'-O-Me Phosphoramidites products provide protected, sequence-addressable building blocks for solid-phase oligonucleotide synthesis and modified-sequence research.
Confirm base and sugar identity, protecting groups, stereochemistry, linker or label position, and compatibility with coupling and deprotection conditions.
Review identity, chromatographic purity, phosphorus-related quality attributes, water sensitivity and performance in a short test sequence.
Product-family considerations
- Phosphoramidite chemistry is modular, automated and compatible with fast sequence iteration.
- Modified sugar, base or linker motifs let researchers tune duplex stability, specificity, hydrophobicity, steric profile and downstream conjugation options.
- Common ribose modifications can improve nuclease resistance and modulate RNA-like binding behavior.
- Modified amidites can require adjusted coupling time, activator choice, deprotection conditions and analytical release methods.
- Moisture sensitivity and storage history are important because degraded amidite can reduce coupling efficiency.
Category literature
These publications provide background for the 2'-O-Me Phosphoramidites product family. Individual product pages only show additional product- or feature-relevant references.
Selection checklist
| Exact identity | Match the canonical name with a CAS number, structure, SMILES or drawing; confirm stereochemistry, protecting groups and salt form where applicable. |
|---|---|
| Specification | Define target purity, analytical method, water or residual-solvent concerns and any application-specific acceptance limits. |
| Workflow fit | Share the reaction, enzyme, sequence, solvent system, support or analytical method used to evaluate compatibility. |
| Supply need | Provide initial quantity, expected future scale, packaging preference, timeline and documentation requirements. |
46 products
DMTr-2'-O-Me-rU-3'-(L)-DPSE-Phosphoramidite99.98% · CAS: 1528733-97-2
BX-2OMP-0065
DMTr-2'-O-Me-rA(Bz)-3'-(L)-DPSE-Phosphoramidite≥98% · CAS: 1528733-90-5
BX-2OMP-0066
6'-O-DMTr-2'-O-Me-5'-Homo-C(Ac)-3'-CE-Phosphoramidite≥98% · CAS: 2714382-70-2
BX-2OMP-0068
6'-O-DMTr-2'-O-Me-5'-Homo-G(iBu)-3'-CE-Phosphoramidite≥98% · CAS: 2714383-00-1
BX-2OMP-0069
DMTr-2'-O-Me-rU-3'-(D)-DPSE-Phosphoramidite≥95% · CAS: 1528733-98-3
BX-2OMP-0070
5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU-3'-CE-Phosphoramidite≥98% · CAS: 2172373-55-4
BX-2OMP-0071
DMTr-2'-O-Me-rC(Bz)-3'-CE Phosphoramidite>98.0% · CAS: 110764-78-8
BX-2OMP-0072
DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite99% · CAS: 110782-31-5
BX-2OMP-0073
DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite≥95% · CAS: 199593-09-4
BX-2OMP-0074
DMTr-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite≥98.0% · CAS: 150780-67-9
BX-2OMP-0075
DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite98.8% · CAS: 110764-79-9
BX-2OMP-0076
5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyl-N4-acetylcytidine-3'-CE phosphoramidite≥98% · CAS: 1883486-16-5
BX-2OMP-0044
5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyluridine-3'-CE phosphoramidite≥98% · CAS: 2747890-15-7
BX-2OMP-0046![Chemical structure of 4'-O-[(Dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-CE-Phosphoramidite](/structures/2d5180e9b8421a7c.jpg)
4'-O-[(Dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-CE-Phosphoramidite≥98% · CAS: 2197181-94-3
BX-2OMP-0015
Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite≥98% · CAS: 2419895-65-9
BX-2OMP-0019
Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rC(Bz)-3'-CE-Phosphoramidite≥98% · CAS: N/A
BX-2OMP-0020
Bis(POM)-(E)-5'-vinylphosphonate-2'-O-Me-rG(iBu)-3'-CE-Phosphoramidite≥98% · CAS: N/A
BX-2OMP-0021
5'-O-DMTr-5-methyl-2'-O-methyluridine-3'-CE phosphoramidite≥98% · CAS: 153631-20-0
BX-2OMP-00565-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-CE phosphoramidite≥98% · CAS: 168611-18-5
BX-2MEP-0001
5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyl-N6-benzoyladenosine-3'-CE phosphoramidite≥98% · CAS: 3060423-81-3
BX-2OMP-0043
5'-O-DMTr-(5'S)-5'-C-methyl-2'-O-methyl-N2-isobutyrylguanosine-3'-CE phosphoramidite≥98% · CAS: N/A
BX-2OMP-0045
5'-O-(Methacrylamide-functionalized trityl)-2'-O-methyluridine-3'-CE phosphoramidite≥98% · CAS: N/A
BX-2OMP-0047![Chemical structure of 4'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-CE-Phosphoramidite](/structures/ffd1032d9375f97e.jpg)
4'-O-[(Hydroxy(methoxy)phosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)≥98% · CAS: N/A
BX-2OMP-0016![Chemical structure of 5'-Deoxy-5'-[(dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-CE-Phosphoramidite](/structures/621f70e934f510a4.jpg)
5'-Deoxy-5'-[(dimethoxyphosphoryl)methyl]-2'-O-methyluridine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)≥98% · CAS: N/A
BX-2OMP-0017![Chemical structure of 5'-O-DMTr-2'-O-Me-6-[3-(3-methoxy-3-oxopropyl)phenyl]purine riboside-3'-CE-Phosphoramidite](/structures/7eb5b6e0ca0e826a.jpg)
5'-O-DMTr-2'-O-Me-6-[3-(3-methoxy-3-oxopropyl)phenyl]purine riboside-3'-CE-Phosphoramidite≥98% · CAS: N/A
BX-2OMP-0025
5'-O-DMTr-2'-O-Me-N2,N6-bis(isobutyryl)-2-aminoadenosine-3'-CE-Phosphoramidite≥98% · CAS: 160526-51-2
BX-2OMP-0026
5'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(L)-PSM phosphoramidite≥98% · CAS: N/A
BX-2OMP-0038
5'-O-DMTr-2'-O-Me-uridine-3'-(L)-PSM phosphoramidite≥98% · CAS: 2963598-67-4
BX-2OMP-0041
5'-O-DMTr-(5'R)-5'-C-methyl-2'-O-methyl-N6-benzoyladenosine-3'-CE phosphoramidite≥98% · CAS: 3055727-88-0
BX-2OMP-0042
2'-O-Me-2-thio-U-3'-phosphoramidite≥98% · CAS: 302918-84-9
BX-2MEP-0004
6'-O-DMTr-2'-O-Me-5'-Homo-A(Bz)-3'-CE-Phosphoramidite≥98% · CAS: 2750354-56-2
BX-2OMP-0023
6'-O-DMTr-2'-O-Me-5'-Homo-U-3'-CE-Phosphoramidite≥98% · CAS: 2714382-62-2
BX-2OMP-0024
5'-O-DMTr-2'-O-Me-N6-benzoyl-N6-methyladenosine-3'-CE-Phosphoramidite≥98% · CAS: 2659239-32-2
BX-2OMP-0028
5'-O-DMTr-2'-O-methylpseudouridine-3'-CE-Phosphoramidite≥98% · CAS: 199737-09-2
BX-2OMP-0029
5'-O-DMTr-2'-O-Me-N6-benzoyladenosine-3'-(D)-DPSE phosphoramidite≥98% · CAS: 1528733-91-6
BX-2OMP-0030
5'-O-DMTr-2'-O-Me-N6-benzoyladenosine-3'-(D)-PSM phosphoramidite≥98% · CAS: 2379296-27-0
BX-2OMP-0031
5'-O-DMTr-2'-O-Me-N6-benzoyladenosine-3'-(L)-PSM phosphoramidite≥98% · CAS: 2379296-17-8
BX-2OMP-0032
DMTr-2'-O-Me-rG(dmf)-3'-CE-Phosphoramidite≥98% · CAS: 128219-77-2
BX-2OMP-0035
5'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(D)-DPSE phosphoramidite≥98% · CAS: 2227139-99-1
BX-2OMP-0036
DMTr-2'-O-Me-rI-3'-CE-Phosphoramidite≥98% · CAS: 128219-85-2
BX-2OMP-0039![Chemical structure of 5'-O-DMTr-2'-O-Me-N2-isobutyryl-N6-[(dimethylamino)methylene]-2-aminoadenosine-3'-CE-Phosphoramidite](/structures/ae0243df747ebfef.jpg)
5'-O-DMTr-2'-O-Me-N2-isobutyryl-N6-[(dimethylamino)methylene]-2-aminoadenosine-3'-CE-Phosphoramidite≥98% · CAS: N/A
BX-2OMP-0027
DMTr-2'-O-Me-rC(Ac)-3'-(L)-PSM-Phosphoramidite≥98% · CAS: N/A
BX-2OMP-0033
5'-O-DMTr-2'-O-Me-N2-isobutyrylguanosine-3'-(L)-DPSE phosphoramidite≥98% · CAS: 2227139-95-7
BX-2OMP-0037
5'-O-DMTr-N4-benzoyl-5-methyl-2'-O-methylcytidine-3'-CE phosphoramidite≥98% · CAS: 166593-57-3
BX-2OMP-0055
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-N6-methyladenosine 3'-CED phosphoramidite≥98% · CAS: 2348385-04-4
BX-2MEP-0003
N2,N6-Diphenoxyacetyl-5'-O-DMTr-2'-O-methyl-2,6-diaminopurine riboside 3'-CE phosphoramidite≥98% · CAS: N/A
BX-2MEP-0002Frequently asked questions
What are typical uses for 2'-O-Me Phosphoramidites?
2'-O-Me Phosphoramidites products provide protected, sequence-addressable building blocks for solid-phase oligonucleotide synthesis and modified-sequence research.
What should be confirmed before ordering 2'-O-Me Phosphoramidites?
Confirm base and sugar identity, protecting groups, stereochemistry, linker or label position, and compatibility with coupling and deprotection conditions.
Are custom quantities or related analogs available?
BX Lab reviews custom package sizes, catalog-adjacent analogs and research-use custom synthesis requests against the target structure, purity, scale and timeline.
Need help selecting a product?
Tell our scientists about your target chemistry, workflow, required purity and scale. We can help identify a catalog product, related analog or custom route.