2'-O-Me Phosphoramidites
DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite as a specialty phosphoramidite building block for solid-phase oligonucleotide synthesis. CAS 110764-79-9. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C40H49N4O9P; molecular weight 760.82).
DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite — DMT-2'O-Methyl-rU Phosphoramidite is a white to off-white powder and is used as a pharmaceutical intermediate for pharmaceutical synthesis and scientific research.
For DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite, reported solubility: DMSO: 100 mg/mL (131.44 mM; Need ultrasonic). Storage: Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-2'-O-Me-rU-3'-CEDPA
- 2’-O-methyl-rUPhosphoramidite
- 5'-DMT-2'-OMe-rU Phosphoramidite
- DMT-2′O-Methyl-rU Phosphoramidite
- 5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite
- N-blocked-5'-O-DMT-2'-O-Me CED uridine phosphoramidite
- 2'-Deoxy-2'-O-Me-5'-O-DMT-Uridine-3'-CED PhosphoraMidite
- 5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-Uridine-3'-CE-Phosphoramidite
Useful catalog search terms
- CAS 110764-79-9
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-methyl modification
- phosphoramidite coupling group
- 2'-OMe-U Phosphoramidite
- BX-2OMP-0051
- 2'-O-Me Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification; phosphoramidite coupling group |
|---|---|
| Form | powder |
| Color | white to off-white |
| SMILES | C(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)(C1C=CC(OC)=CC=1)OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C |&1:25,27,36,39,r| |
| InChIKey | UVUOJOLPNDCIHL-XKZJCBTISA-N |
| InChI | InChI=1S/C40H49N4O9P/c1-27(2)44(28(3)4)54(51-25-11-23-41)53-36-34(52-38(37(36)49-7)43-24-22-35(45)42-39(43)46)26-50-40(29-12-9-8-10-13-29,30-14-18-32(47-5)19-15-30)31-16-20-33(48-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,46)/t34-,36-,37-,38-,54?/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0076 and CAS 110764-79-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry.