2'-F Nucleosides
2'-Deoxy-2'-fluoro-3',5'-di-O-acetyluridine
Quick view. We supply 2'-Deoxy-2'-fluoro-3',5'-di-O-acetyluridine as a 2'-fluoro nucleoside for modified nucleotide, amidite and nucleoside analog synthesis. CAS 10212-13-2. Catalog target purity: Specification on request.
Product profile
2'-Deoxy-2'-fluoro-3',5'-di-O-acetyluridine is classified as nucleoside or protected nucleoside intermediate (Formula C13H15FN2O7; molecular weight 330.27).
2'-Deoxy-2'-fluoro-3',5'-di-O-acetyluridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-Deoxy-2'-fluoro-3',5'-di-O-acetyluridine, reported solubility: DMSO (Slightly), Methanol (Slightly). Storage: Hygroscopic, Refrigerator, under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- 1-(3-C-Acetyl-2,7-dideoxy-2-fluoroheptofuranosyl-6-ulose)pyrimidine-2,4(1H,3H)-dione
- 3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE
- 1-[4-acetyl-3-fluoro-4-hydroxy-5-(1-hydroxy-2-oxopropyl)-2-oxolanyl]pyrimidine-2,4-dione
Useful catalog search terms
- CAS 10212-13-2
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-F Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| InChI | InChI=1S/C13H15FN2O7/c1-5(17)8(20)10-13(22,6(2)18)9(14)11(23-10)16-4-3-7(19)15-12(16)21/h3-4,8-11,20,22H,1-2H3,(H,15,19,21) |
| InChIKey | ZCLGRIWTXYMHLM-UHFFFAOYSA-N |
| SMILES | CC(=O)C(O)C1OC(n2ccc(O)nc2=O)C(F)C1(O)C(C)=O |
| Melting point | 174-177°C |
| Density | 1.45±0.1 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoro-3',5'-di-O-acetyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-Deoxy-2'-fluoro-3',5'-di-O-acetyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0006 and CAS 10212-13-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry.